Fraxiparine

Fraxiparine

nadroparin

Manufacturer:

Aspen

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Nadroparin Ca
Indications/Uses
Prophylaxis of thromboembolic disease in patients undergoing general or orthopaedic surgery, those in high risk medical patients (eg, resp failure &/or infections &/or cardiac failure), immobilised due to acute illness or hospitalised in ICU. Thromboembolic disorders, unstable angina & non-Q wave MI. Prevention of clotting during haemodialysis.
Dosage/Direction for Use
Adult Prophylaxis of thromboembolic disorders in general surgery 0.3 mL SC daily 2-4 hr pre-op for at least 7 days. Orthopaedic surgery ≥70 kg 0.4 mL SC 12 hr pre- & post-op then once daily on day 3, 0.6 mL from day 4 onwards, 50-69 kg 0.3 mL 12 hr SC pre- & post-op then once daily on day 3, 0.4 mL from day 4 onwards, <50 kg 0.2 mL SC 12 hr pre- & post-op then once daily on day 3, 0.3 mL from day 4 onwards. Min duration: 10 days. High-risk medical patient, immobilised due to acute illness or hospitalised in ICU >70 kg 0.6 mL SC once daily, ≤70 kg 0.4 mL SC once daily. Thromboembolic disorders ≥90 kg 0.9 mL SC bd, 80-89 kg 0.8 mL SC bd, 70-79 kg 0.7 mL SC bd, 60-69 kg 0.6 mL SC bd, 50-59 kg 0.5 mL SC bd, <50 kg 0.4 mL SC bd. Usual duration: 10 days. Prevention of clotting during haemodialysis for patient w/o risk of haemorrhage Administered as single dose inj into arterial line at start of each session, ≥70 kg 0.6 mL, 50-69 kg 0.4 mL, <50 kg 0.3 mL. Unstable angina & non-Q wave MI Initial dose given as IV bolus & subsequent doses as SC inj 12 hrly in combination w/ aspirin 325 mg daily, ≥100 kg 1 mL, 90-99 kg 0.9 mL, 80-89 kg 0.8 mL, 70-79 kg 0.7 mL, 60-69 kg 0.6 mL, 50-59 kg 0.5 mL, <50 kg 0.4 mL.
Contraindications
Hypersensitivity. History of thrombocytopenia. Active bleeding or increased risk of haemorrhage in relation w/ haemostasis disorders except for disseminated intravascular coagulation not induced by heparin; organic lesion likely to bleed eg, active peptic ulceration; haemorrhagic CVA; acute infectious endocarditis. Severe renal impairment (CrCl <30 mL/min) in patients receiving treatment for thromboembolic disorders, unstable angina & non-Q wave MI.
Special Precautions
Not to be used interchangeably w/ other LMWH during ongoing treatment. Not to be inj IM. Heparin-induced thrombocytopenia. Increased risk of bleeding eg, severe arterial HTN, history of peptic ulceration or other organic lesion likely to bleed, vascular chorioretinal disorder; post-op brain, spinal cord or eye surgery; spinal/epidural anaesth/spinal lumbar puncture; cutaneous necrosis. Patients w/ raised plasma K or at risk of increased plasma K levels eg, patients w/ DM, pre-existing metabolic acidosis. Frequently monitor signs & symptoms of neurological impairment. Monitor platelet counts throughout course of treatment. May cause severe allergic reaction due to latex. Concomitant use w/ drugs causing hyperkalemia eg, ACE inhibitors, NSAIDs; platelet inhibitors, other anticoagulants; aspirin, other salicylates. Renal impairment; chronic renal failure. Hepatic impairment & failure. Pregnancy. Not to be used during lactation. Not recommended in childn & adolescents <18 yr. Elderly.
Adverse Reactions
Haemorrhagic manifestations at various sites; inj site haematoma. Transient increased transaminases; inj site reaction.
Drug Interactions
Oral anticoagulants, systemic glucocorticosteroids, dextrans.
MIMS Class
Anticoagulants, Antiplatelets & Fibrinolytics (Thrombolytics)
ATC Classification
B01AB06 - nadroparin ; Belongs to the class of heparin group. Used in the treatment of thrombosis.
Presentation/Packing
Form
Fraxiparine soln for inj (pre-filled syringe) 2,850 anti-Xa IU
Packing/Price
0.3 mL x 10 × 1's
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