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Indications and Dosage
Intramuscular
Advanced breast cancer in postmenopausal women Adult: 250 mg every 2 wk into each buttock alternately.
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Contraindications
Women with premenopausal endocrine status, pregnancy, lactation.
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Special Precautions
Avoid unintentional intravascular inj or inj into or near the sciatic nerve. Do not inject into areas with resistance or showing inflammation from previous admin. Monitor blood glucose in diabetics. Caution if driving or operating machinery.
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Adverse Reactions
Local irritation and pain at the site of inj, hot flushes, rashes, drowsiness, dizziness, emotional lability, oedema of the leg, thrombophloebitis, vaginal spotting or bleeding, GI disturbances, muscle cramps, arthralgia and vasovagal reaction.
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Action
Description:
Mechanism of Action: Formestane has anti-oestrogenic properties as seen in the inhibition of the oestrogen synthetase (aromatase) system which is essential in the production of oestrogens from androgens. Pharmacokinetics: Distribution: About 85% bound to plasma proteins. Metabolism: Metabolised by conjugation to the inactive glucuronide. Excretion: Apparent elimination half-life: 5-6 days. <1% of the dose is excreted unchanged in urine. |
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MIMS Class
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