Discontinue use if allergic or anaphylactic-type reactions occur. History of CHD or MI, peri- or post-op patients, patients at risk of thromboembolic events or disseminated intravascular coagulation. Carefully monitor coagulation system. Possibility of transmitting infective agents. Consider hepatitis A & B vaccination for patients in regular/repeated receipt of human plasma-derived products. Patients on controlled Na diet. Hepatic disease. Pregnancy & lactation. Neonates. Elderly ≥65 yr.