Recommended dose: 50-100 U/kg; not to exceed 100 U/kg as single dose & max: 200 U/kg daily.
Minor to moderate joint, muscle & soft tissue hemorrhage 50-75 U/kg at 12-hr intervals.
Severe muscle & soft tissue bleeding eg, retroperitoneal hemorrhage 100 U/kg at 12-hr intervals.
Mucous membrane hemorrhage 50 U/kg every 6 hr, may be increased to 100 U/kg. Max: Not to exceed 200 U/kg daily.
Other severe hemorrhages eg, CNS bleeding 100 U/kg at 12-hr intervals, may be administered at 6-hr intervals. Max: Not to exceed 200 U/kg daily.
Pre-op Initially 100 U/kg, then 50-100 U/kg after 6-12 hr.
Post-op maintenance dose 50-100 U/kg at 6-12 hr intervals. Max: Not to exceed 200 U/kg daily.
Prophylaxis of bleeding in patient w/ high inhibitor titer & frequent hemorrhages after failed immune tolerance induction (ITI) or when ITI is not considered 70-100 U/kg every other day, may be increased to 100 U/kg daily or may be decreased gradually.
Prophylaxis of bleeding in patient w/ high inhibitor titer during ITI 50-100 U/kg bd w/ concomitant factor VIII administration.
Sign Out
