Decreased C
max & increased AUC w/ strong CYP2C8 inhibitors. Decreased C
max w/ strong CYP3A4 inhibitors. Monitor for AR w/ CYP2B6 substrates. Decreased AUC of midazolam, omeprazole, warfarin, fexofenadine, rosuvastatin. Lowered exposure to darunavir, felodipine, simvastatin, diazepam, phenytoin, l-thyroxine, valproic acid. Lowered exposure of colchicine, dabigatran etexilate, digoxin, lapatinib, MTX, repaglinide. QT interval-prolonging drugs or Torsade de pointes-inducing drugs eg, class IA (eg, quinidine, disopyramide) or class III (eg, amiodarone, sotalol, dofetilide, ibutilide) antiarrhythmics, methadone, moxifloxacin, antipsychotics eg, haloperidol.