IV/SC Chronic renal failure Target Hb conc:
Adult 10-12 g/dL.
Childn 9.5-11 g/dL.
Hemodialysis Preferably IV route. Correction phase:
Adult & childn 50 IU/kg 3 times/wk IV, may be increased in increments of 25 IU/kg 3 times/wk at 4-wk intervals. Maintenance phase:
Adult 75-300 IU/kg wkly.
Childn >30 kg 30-100 IU/kg 3 times/wk,
10-30 kg 60-150 IU/kg 3 times/wk,
<10 kg 75-100 IU/kg 3 times/wk.
Peritoneal dialysis Adult Correction phase: 50 IU/kg twice/wk, may be increased in increments of 25 IU/kg twice/wk at 4-wk intervals. Maintenance phase: 25-50 IU/kg twice/wk.
Predialysis Adult Correction phase: 50 IU/kg 3 times/wk, may be increased in increments of 25 IU/kg 3 times/wk at 4-wk intervals. Maintenance phase: 17-33 IU/kg 3 times/wk. Max: 200 IU/kg 3 times/wk.
Cancer patient Target Hb conc: Not to exceed 10-12 g/dL. Initially 150 IU/kg SC 3 times/wk, may be increased to 300 IU/kg SC 3 times/wk after 4 wk of treatment.
Zidovudine-treated, HIV-infected patient Correction phase: 100 IU/kg 3 times/wk for 8 wk, may be increased in increments of 50-100 IU/kg 3 times/wk at 4-wk intervals. Maintenance phase: Titrate dose to maintain hematocrit between 30-35%.
Autologous pre-donation program in surgery 600 IU/kg IV twice/wk for 3 wk prior to surgery.
Perisurgery patient w/o autologous blood donation 600 IU/kg SC wkly for 3 wk (days -21, -14 & -7) prior to & on day of surgery or 300 IU/kg SC daily for 10 days pre-op, on day of surgery & for 4 days post-op.
Adult patient w/ low- or intermediate-1-risk MDS 450 IU/kg SC once wkly, may be increased to 1,050 IU/kg once wkly. Max: 80,000 IU wkly.