Discontinue use if severe infusion-related, anaphylactic or other severe reactions occur or progressive multifocal leukoencephalopathy is confirmed. Not to be administered as IV push or bolus. Not to be initiated in active, severe infections eg, TB, sepsis, cytomegalovirus, listeriosis & opportunistic infections. Controlled chronic or history of recurring severe infection. Increased risk of malignancy. Not recommended in patients previously treated w/ biologic immunosuppressants eg, natalizumab. Concomitant use w/ non-live & live vaccines. May affect ability to drive & use machines. Renal or hepatic impairment. Pregnancy & lactation. Ped patients ≤17 yr.