Econazole: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Malaysia prescribing information.

Generic Medicine Info

Indications and Dosage

Topical/Cutaneous
Nail fungal infections

Adult: As 1% cream or lotion: Apply once daily under occlusive dressing. For tinea pedis: As 1% cream or foam: Apply once daily for 4 wk.
Child: ≥12 yr For tinea pedis: As 1% foam: Apply once daily for 4 wk.

Topical/Cutaneous
Tinea corporis, Tinea cruris, Tinea versicolor

Adult: As 1% cream: Apply once daily for 2 wk.

Topical/Cutaneous
Cutaneous candidiasis

Adult: As 1% cream: Apply bid (morning and evening) for 2 wk.

Vaginal
Vaginal candidiasis

Adult: As pessary: Insert 150 mg pessary intravaginally at bedtime for 3 consecutive nights, or as single dose in long-acting preparations.

Contraindications

Hypersensitivity.

Special Precautions

Patient using spermicidal contraceptives. Pregnancy and lactation.

Adverse Reactions

Burning and stinging sensation, pruritus, erythema, rash; contact dermatitis.

Pregnancy Category (US FDA)

Topical: C

Patient Counseling Information

May damage latex contraceptive diaphragms and condoms, avoid use during treatment. Avoid contact w/ eyes, nose, mouth or other mucous membranes. Avoid heat, flame and smoking upon application of foam preparation.

Drug Interactions

May enhance anticoagulant effect of warfarin or acenocoumarol.

Action

Description:
Mechanism of Action: Econazole modifies the permeability of cell wall membrane in fungi; may interfere w/ RNA and protein synthesis, and lipid metabolism.
Pharmacokinetics:
Absorption: Insignificant (topical or vaginal).

Chemical Structure

Storage

Store between 15-30°C.

MIMS Class

Preparations for Vaginal Conditions / Topical Antifungals & Antiparasites

References

Anon. Econazole. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 22/07/2014.

Buckingham R (ed). Econazole. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 21/07/2014.

Econazole Nitrate Cream (Prasco Laboratories). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 22/07/2014.

Ecoza Aerosol, Foam (Quinnova Pharmaceuticals, LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 22/07/2014.

McEvoy GK, Snow EK, Miller J et al (eds). Econazole Nitrate (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 22/07/2014.

Disclaimer: This information is independently developed by MIMS based on Econazole from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2024 MIMS. All rights reserved. Powered by MIMS.com