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Recurrent miscarriage
Adult: For cases associated with proven progesterone deficiency: 10 mg bid until the 12th or 20th week of pregnancy.
Oral
Endometrial protection during menopausal hormonal replacement therapy, Mild vasomotor symptoms associated with menopause, Moderate vasomotor symptoms associated with menopause, Prophylaxis of postmenopausal osteoporosis
Adult: In combination with continuous estrogen treatment (continuous sequential therapy): 10 mg daily for 14 consecutive days of a 28-day cycle. In combination with cyclical estrogen therapy (cyclic treatment): 10 mg daily for the last 12-14 days of estrogen treatment. Doses may be adjusted to 20 mg daily depending on clinical response (e.g. endometrial biopsy, ultrasound reveal).
Oral
Threatened miscarriage
Adult: For cases associated with proven progesterone deficiency: Initially, up to 40 mg loading dose, followed by 10 mg 8 hourly until symptoms remit.
Oral
Endometriosis
Adult: 10-30 mg daily from day 5-25 of the cycle, or continuously.
Oral
Infertility due to luteal insufficiency
Adult: 10 mg daily from day 14-25 of the cycle for at least 6 months. Alternatively, 10 or 20 mg daily starting on the 2nd half of the menstrual cycle until the 1st day of the next cycle. Maintain treatment for at least 3 consecutive cycles.
Oral
Dysmenorrhoea
Adult: 10 or 20 mg daily from day 5-25 of the cycle.
Oral
Dysfunctional uterine bleeding
Adult: For arresting a bleeding episode: 10 mg bid for 5-7 days. Alternatively, 20 or 30 mg daily may be given for up to 10 days. For continued prevention: 10 or 20 mg daily from day 11-25 of the cycle. Treatment guidelines may vary between countries as some may recommend dydrogesterone to be used in combination with estrogen. Refer to local detailed product information.
Oral
Secondary amenorrhoea
Adult: In combination with estrogen (endogenous or exogenous) to adequately prime the endometrium: 10 or 20 mg daily from day 11-25 of the menstrual cycle.
Oral
Premenstrual syndrome
Adult: 10 mg bid from day 11-25 of the cycle. Alternatively, 10 mg bid starting on the 2nd half of the menstrual cycle until the 1st day of the next cycle; initial treatment day and duration will depend on the individual cycle length.
Oral
Irregular menstrual cycle
Adult: 10 mg bid from day 11-25 of the cycle. Alternatively, 10 or 20 mg daily starting on the 2nd half of menstrual cycle until the 1st day of next cycle; initial treatment day and duration will depend on the individual cycle length.
Oral
Luteal support during assisted reproductive technology
Adult: 10 mg tid starting at the day of oocyte retrieval and continued for 10 weeks if pregnancy is confirmed. Discontinue treatment upon diagnosis of miscarriage or abortion.
