Increased cisapride & terfenadine plasma levels. Decreased astemizole clearance. Inhibition of pimozide, quinidine, carbamazepine, losartan metabolism. Increased risk of cardiotoxicity w/ erythromycin. Increased QT prolongation w/ amiodarone. Increased lemborexant, celecoxib, tolvaptan, voriconazole, zidovudine C
max & AUC. Increased plasma conc by hydrochlorothiazide. Decreased AUC & shorter t
½ w/ rifampicin. Increased plasma conc of other CYP2C9-, CYP2C19- & CYP3A4-metabolized compd; ibrutinib, lurasidone, olaparib, saquinavir, halofantrine, sirolimus, tacrolimus. Reduced clearance, distribution vol & prolonged t
½ of alfentanil. Increased amitriptyline & nortriptyline effects. Increased prothrombin time w/ warfarin. Increased conc & psychomotor effects w/ midazolam. Increased AUC of triazolam, cyclosporine, ethinyl estradiol & levonorgestrel. Increased systemic exposure of Ca-channel blockers, tofacitinib. Increased serum bilirubin & creatinine w/ cyclophosphamide. Delayed fentanyl elimination. Increased risk of myopathy & rhabdomyolysis w/ HMG-CoA reductase inhibitors. Increased ivafactor exposure. Enhanced serum conc of methadone. Potentially increased systemic exposure of NSAIDs metabolized by CYP2C9 eg, naproxen, lornoxicam, meloxicam, diclofenac. Inhibits hepatic metabolism of phenytoin. Increased metabolism of prednisone. Increased serum levels of rifabutin, vinca alkaloids eg, vincristine & vinblastine. Prolonged serum t
½ of oral sulfonylureas eg, chlorpropamide, glibenclamide, glipizide, tolbutamide. Decreased mean plasma clearance rate of theophylline. Developed CNS undesirable effects w/ vit A.