Adult Pneumonia, UTI, gynaecological infections eg, endometritis 500 mg IV every 8 hr. Hospital-acquired pneumonia, peritonitis, presumed infections in febrile neutropenic patient, septicaemia 1 g IV every 8 hr. Meningitis 2 g every 8 hr. Pseudomonas aeruginosa nosocomial infections Adult & adolescent Up to 2 g tds. ChildnInfections>50 kg Adult dose, >3 mth-12 yr 10-20 mg/kg every 8 hr. Meningitis 40 mg/kg every 8 hr. Febrile episodes in neutropenic patient 20 mg/kg every 8 hr. Pseudomonas aeruginosa nosocomial infections Up to 40 mg/kg tds.
History of hypersensitivity reactions to carbapenems, β-lactam antibiotics, penicillins & cephalosporins. Not recommended for MRSA infections. Overgrowth of nonsusceptible organisms; Clostridium difficile-associated diarrhea, pseudomembranous colitis; CNS disorders (eg, brain lesions or history of seizures), bacterial meningitis. History of GI complaints. Monitor transaminase & bilirubin levels. Co-administration w/ potentially nephrotoxic drugs. Renal impairment. Hepatic disease. Not to be used during pregnancy & lactation. Childn w/ altered hepatic or renal function. Not recommended in infant <3 mth.
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