Anaphylactic-like reactions, history of atopy. Myelosuppression; anaemia; nausea, vomiting; ototoxicity; hypomagnesaemia & hypocalcaemia; peripheral neuropathy, postural hypotension, myasthenic syndromes, seizures, loss of vision; CV toxicity. Ensure adequate hydration to minimise risk of nephrotoxicity. Monitor renal function including GFR, BUN, serum creatinine & CrCl, electrolytes, auditory function, RBC, WBC, platelets, liver function & neurological status prior to & during treatment. Not to be used w/ live vaccines. Hepatic & renal impairment, preexisting hepatic & renal dysfunction. May affect male & female fertility. Women of childbearing potential should use effective contraception. Not recommended during pregnancy. Not to be used during lactation.