Leucovorin Ca rescue in impaired MTX elimination or inadvertent overdosage 10 mg/m
2 IV or IM every 6 hr until serum MTX level is <10
-8 M. If 24-hr serum creatinine >50% or MTX level >5 x 10
-6 M or 48-hr level >9 x 10
-7 M, increase dose to 100 mg/m
2 IV every 3 hr until MTX level <10
-8 M.
Leucovorin Ca rescue after high-dose MTX therapy 15 mg every 6 hr for 10 doses starting 24 hr after MTX infusion until MTX level <5 x 10
-8 M.
Megaloblastic anaemia due to folic acid deficiency Up to 1 mg daily.
Advanced CRC 200 mg/m
2 slow IV inj over min of 3 min, followed by 5-fluorouracil 370 mg/m
2 IV inj or 20 mg/m
2 IV inj followed by 5-fluorouracil 425 mg/m
2 IV inj for 5 days. May be repeated at 4-wk (28 days) intervals for 2 courses & then repeated at 4-5 wk (28-35 days) intervals provided that patient has completely recovered.
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