Adult ≥18 yr Monotherapy & in combination w/ lenalidomide & low-dose dexamethasone 16 mg/kg IV infusion as 4-wk cycle regimen. Wk 1-8: Wkly (total: 8 doses). Wk 9-24: Every 2 wk, 1st dose to be given at wk 9 (total: 8 doses). Wk 25 onwards until disease progression: Every 4 wk, 1st dose to be given at wk 25.
In combination w/ bortezomib, melphalan & prednisone 16 mg/kg IV infusion as 6-wk cycle regimen. Wk 1-6: Wkly (total: 6 doses). Wk 7-54: Every 3 wk, 1st dose to be given at wk 7 (total: 16 doses). Wk 55 onwards until disease progression: Every 4 wk, 1st dose to be given at wk 55. Bortezomib is given twice wkly at Wk 1, 2, 4 & 5 for 1st 6-wk cycle, followed by once wkly at Wk 1, 2, 4 & 5 for 8 more 6-wk cycles.
In combination w/ carfilzomib & dexamethasone 4-wk cycle regimen: Wk 1: 8 mg/kg on days 1 & 2 (total: 2 doses). Wk 2-8: 16 mg/kg wkly (total: 7 doses). Wk 9-24: 16 mg/kg every 2 wk, 1st dose to be given at wk 9 (total: 8 doses). Wk 25 onwards until disease progression: 16 mg/kg every 4 wk, 1st dose to be given at wk 25 (dose based on actual body wt).
In combination w/ bortezomib & dexamethasone 16 mg/kg IV infusion as 3-wk cycle regimen. Wk 1-9: Wkly (total: 9 doses). Wk 10-24: Every 3 wk, 1st dose to be given at wk 10 (total: 5 doses). Wk 25 onwards until disease progression: Every 4 wk, 1st dose to be given at wk 25.
In combination w/ bortezomib, thalidomide & dexamethasone 16 mg/kg IV infusion as 4-wk cycle regimen. Induction phase: Wk 1-8: Wkly (total: 8 doses). Wk 9-16: Every 2 wk, 1st dose to be given at wk 9 (total: 4 doses). Stop for high-dose chemotherapy & ASCT. Consolidation phase: Wk 1-8: Every 2 wk, 1st dose to be given at wk 1 upon re-initiation of treatment following ASCT (total: 4 doses).