Consider premed & baseline testing during treatment.
MDS 3-day regimen: 15 mg/m
2 by continuous IV infusion over 3 hr repeated every 8 hr for 3 days; repeat cycle every 6 wk for min of 4 cycles. Complete or partial response may take longer than 4 cycles. Delay & reduce dose for hematologic toxicity. 5-day regimen: 20 mg/m
2 by continuous IV infusion over 1 hr daily for 5 days. Delay & reduce dose for hematologic toxicity. Repeat cycle every 4 wk upon hematologic recovery for min of 4 cycles. Complete or partial response may take longer than 4 cycles.
AML 20 mg/m
2 by IV infusion over 1 hr repeated daily for 5 consecutive days. Total daily dose: Not to exceed 20 mg/m
2; total dose/treatment cycle: Not to exceed 100 mg/m
2. Repeat cycle every 4 wk depending on patient's clinical response & observe toxicity.
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