Cubicin

Cubicin

daptomycin

Manufacturer:

Merck Sharp & Dohme

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Daptomycin
Indications/Uses
Complicated skin & skin structure infections (cSSSI). Staph aureus bloodstream infections (bacteremia) including those w/ right-sided infective endocarditis, caused by methicillin-susceptible & -resistant isolates.
Dosage/Direction for Use
cSSSI Adult 4 mg/kg IV infusion over 30 min once every 24 hr for 7-14 days. Childn 12-17 yr 5 mg/kg IV infusion over 30 min once every 24 hr for up to 14 days, 7-11 yr 7 mg/kg IV infusion over 30 min once every 24 hr for up to 14 days, 2-6 yr 9 mg/kg IV infusion over 60 min once every 24 hr for up to 14 days, 1 to <2 yr 10 mg/kg IV infusion over 60 min once every 24 hr for up to 14 days. CrCl ≥30 mL/min 4 mg/kg once every 24 hr, <30 mL/min including hemodialysis & continuous ambulatory peritoneal dialysis (CAPD) 4 mg/kg once every 48 hr. Staph aureus bloodstream infections (bacteremia) Adult 6 mg/kg IV infusion over 30 min once every 24 hr for 2-6 wk. Childn 12-17 yr 7 mg/kg IV infusion over 30 min once every 24 hr for up to 42 days, 7-11 yr 9 mg/kg IV infusion over 30 min once every 24 hr for up to 42 days, 1-6 yr 12 mg/kg IV infusion over 60 min once every 24 hr for up to 42 days. CrCl ≥30 mL/min 6 mg/kg once every 24 hr, <30 mL/min including hemodialysis & CAPD 6 mg/kg once every 48 hr.
Contraindications
Special Precautions
Discontinue use if anaphylaxis/hypersensitivity reactions, unexplained signs & symptoms of myopathy, recurrence of eosinophilic pneumonia occurs; DRESS &/or tubulointerstitial nephritis; Clostridium difficile-associated diarrhea is suspected. Not indicated for pneumonia & left-sided infective endocarditis due to Staph aureus; prosthetic valve endocarditis. Peripheral neuropathy; persisting or relapsing Staph aureus bacteremia/endocarditis. Overgrowth of non-susceptible organisms. False prolongation of prothrombin time & elevation of INR. Monitor creatine phosphokinase levels at baseline & at regular intervals. Renal & severe hepatic impairment. Pregnancy. Avoid use during lactation. Not to be given to ped patients <1 yr.
Adverse Reactions
Anemia; GI & abdominal pain, diarrhea, vomiting, flatulence, bloating, distention, constipation, nausea; asthenia, pyrexia, infusion site reaction; UTI, fungal & Candida infection; increased blood creatine phosphokinase, abnormal LFT; limb pain; dizziness, headache; anxiety, insomnia; pruritus, rash; HTN, hypotension.
Drug Interactions
Monitor anticoagulant activity w/ warfarin. Caution w/ tobramycin; HMG-CoA reductase inhibitors. Incompatibility w/ dextrose-containing diluents. Not to be used in conjunction w/ ReadyMED elastomeric infusion pumps.
MIMS Class
Other Antibiotics
ATC Classification
J01XX09 - daptomycin ; Belongs to the class of other antibacterials. Used in the systemic treatment of infections.
Presentation/Packing
Form
Cubicin powd for infusion (vial) 500 mg
Packing/Price
10 mL x 1's
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