Initial & maintenance dose: 150 mg once daily, may be increased to 300 mg or other anti-hypertensive agents can be added. Hypertensive type 2 diabetic patient Initially 150 mg once daily, titrated up to 300 mg once daily. Elderly >75 yr & haemodialysis patient Initially 75 mg once daily.
Not recommended in primary aldosteronism & dual blockade of renin-angiotensin-aldosterone system. Bilateral renal artery stenosis or artery stenosis to single functioning kidney; aortic or mitral valve stenosis or obstructive hypertrophic cardiomyopathy; hyperkalaemia; ischaemic cardiopathy or CV disease. Correct vol &/or Na depletion prior to administration. Periodic monitoring of serum K & creatinine levels, electrolytes & BP. Black patients. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Not recommended in combination w/ ACE inhibitors; lithium. May affect ability to drive & use machines. Renal impairment & recent kidney transplantation. Not recommended during 1st trimester of pregnancy & lactation. Not recommended in childn & adolescents.
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