Prophylaxis of VTE disease in surgery Patient w/ moderate thromboembolism risk 2,000 IU SC once daily. 1st inj given 2 hr pre-op. Maintained for min: 7-10 days.
Patient w/ high thromboembolism risk 4,000 IU SC once daily w/ initial dose given 12 hr pre-op. Last inj to be given not >12 hr pre-op & resumed 12 hr post-op.
Patient who undergoes major orthopaedic surgery May extend for up to 5 wk.
Patient w/ high VTE risk who undergoes abdominal or pelvic cancer surgery May extend for up to 4 wk.
Prophylaxis of VTE in medical patient 4,000 IU SC once daily for at least 6-14 days.
DVT & PE 150 IU/kg SC once daily or 100 IU/kg SC bd.
Prevention of thrombus formation during haemodialysis 100 IU/kg introduced into arterial circuit line prior to 4-hr haemodialysis.
Patient w/ high-risk of haemorrhage Reduce dose to 50 IU/kg for double vascular access or 75 IU/kg for single vascular access.
Unstable angina & NSTEMI 100 IU/kg SC every 12 hr in combination w/ antiplatelet therapy for min: 2 days until clinical stabilization. Usual duration: 2-8 days.
Acute STEMI 3,000 IU single IV bolus + 100 IU/kg SC followed by 100 IU/kg SC every 12 hr. Max: 10,000 IU each for 1st 2 SC doses. Recommended duration: 8 days or until hospital discharge.
Elderly ≥75 yr Initially 75 IU/kg SC every 12 hr. Max: 7,500 IU each for 1st 2 SC doses, followed by 75 IU/kg SC for the remaining doses.
Patient managed w/ PCI 30 IU/kg IV bolus if last SC inj was given >8 hr before balloon inflation.