Tab Adult & adolescent ≥12 yr Mild reflux disease & associated symptoms 20 mg daily for 2-4 wk.
Long-term management & prevention of reflux oesophagitis relapse 20 mg daily, may be increased to 40 mg daily. Reduce to 20 mg daily once relapse is controlled.
Moderate & severe reflux oesophagitis 40 mg daily, may be increased to 2-tab 40 mg daily. Duration of treatment: 4-8 wk.
Adult Duodenal & gastric ulcer 40 mg daily, may be increased to 2-tab 40 mg daily. Duration of treatment: Duodenal ulcer 2 wk. Gastric ulcer 4-8 wk.
Prevention of NSAID-induced gastroduodenal ulcers in patient at risk 20 mg daily.
H pylori eradication in gastric or duodenal ulcers 40 mg bd + amoxicillin 1,000 mg bd + clarithromycin 500 mg bd or 40 mg bd + metronidazole 500 mg bd + clarithromycin 500 mg bd or 40 mg bd + amoxicillin 1,000 mg bd + metronidazole 500 mg bd. Duration of treatment: 1-2 wk.
Zollinger-Ellison syndrome & other pathological hypersecretory conditions Initially 80 mg daily, may be titrated up or down as needed.
Inj Gastric & duodenal ulcer, moderate & severe reflux esophagitis 40 mg IV daily if oral therapy is inappropriate.
Zollinger-Ellison syndrome & other pathological hypersecretory conditions Initially 80 mg IV daily, titrate dose as needed.