Adjunct to l-dopa/benserazide or l-dopa/carbidopa in patients w/ Parkinson's disease & end-of-dose motor fluctuations who cannot be stabilized on those combinations.
Discontinue use if prolonged or persistent diarrhoea occurs. Rhabdomyolysis secondary to severe dyskinesias or NMS; ischaemic heart disease; somnolence, sudden sleep onset episodes. May aggravate l-dopa-induced orthostatic hypotension. Monitor/follow-up of wt in patients experiencing diarrhoea. Regularly monitor for development of impulse control disorders. Perform general medical evaluation including hepatic function in case of progressive anorexia, asthenia & decreased wt. Not to be taken by patients w/ fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency. Avoid abrupt discontinuation. Concomitant use w/ COMT-metabolized medicinal products eg, rimiterol, isoprenaline, adrenaline, noradrenaline, dopamine, dobutamine, α-methyldopa, apomorphine; medicinal products causing orthostatic hypotension; dopamine agonists (eg, bromocriptine), selegiline or amantadine. May impair ability to drive & use machines. Dialysis patients. Not to be used during pregnancy & lactation. Not recommended in childn <18 yr.
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