Lamivudine: Decreased AUC & C
max w/ sorbitol. Increased exposure w/ trimethoprim/sulphamethoxazole. Inhibited intracellular phosphorylation of emtricitabine. Zidovudine: Decreased metabolism rate by atovaquone. Reduced absorption by clarithromycin. Low phenytoin blood levels. Reduced renal excretion w/ probenecid. Inhibited intracellular phosphorylation of stavudine. Altered metabolism by aspirin, codeine, morphine, methadone, indomethacin, ketoprofen, naproxen, oxazepam, lorazepam, cimetidine, clofibrate, dapsone & isoprinosine. Increased risk of ARs w/ potentially nephrotoxic or myelosuppresive drugs.