Combivir

Combivir

lamivudine + zidovudine

Manufacturer:

GlaxoSmithKline

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Lamivudine 150 mg, zidovudine 300 mg
Dosage/Direction for Use
Adult & adolescent at least 30 kg 1 tab bd. Childn 21-30 kg ½ tab in the morning & 1 tab in the evening,14-21 kg ½ tab bd.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to lamivudine, zidovudine. Abnormally low neutrophil counts (<0.75 x 109/L) or Hb levels (<7.5 g/dL or 4.65 mmol/L).
Special Precautions
Discontinue use if pancreatitis occurs. Opportunistic & other complications of HIV infection. Lactic acidosis & severe hepatomegaly w/ steatosis. Lipoatrophy; immune reconstitution syndrome. Patients co-infected w/ HBV & HCV. Manage serum lipids & blood glucose. Monitor haematological parameters. Known risk factors for liver disease. Severe hepatic or renal (CrCl <50 mL/min) impairment. Pregnancy & lactation. Elderly.
Adverse Reactions
Hyperlactataemia; headache; nausea, vomiting, upper abdominal pain, diarrhoea; malaise. Lamivudine: Rash, alopecia; arthralgia, muscle disorders; fatigue, fever. Zidovudine: Anaemia, neutropenia, leucopenia; dizziness, raised blood levels of liver enzymes & bilirubin, myalgia.
Drug Interactions
Lamivudine: Decreased AUC & Cmax w/ sorbitol. Increased exposure w/ trimethoprim/sulphamethoxazole. Inhibited intracellular phosphorylation of emtricitabine. Zidovudine: Decreased metabolism rate by atovaquone. Reduced absorption by clarithromycin. Low phenytoin blood levels. Reduced renal excretion w/ probenecid. Inhibited intracellular phosphorylation of stavudine. Altered metabolism by aspirin, codeine, morphine, methadone, indomethacin, ketoprofen, naproxen, oxazepam, lorazepam, cimetidine, clofibrate, dapsone & isoprinosine. Increased risk of ARs w/ potentially nephrotoxic or myelosuppresive drugs.
MIMS Class
Antivirals
ATC Classification
J05AR01 - zidovudine and lamivudine ; Belongs to the class of antivirals for treatment of HIV infections, combinations.
Presentation/Packing
Form
Combivir FC tab
Packing/Price
60's
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