Hypersensitivity to sulfonamide or trimethoprim. Marked liver parenchymal damage. Not to be given to patients w/ serious haematological disorder. G6PD deficiency. Severe renal insufficiency. Pregnancy. Premature & newborn babies during 1st wk of life.
Discontinue use if skin rash appears. Folic acid deficiency; blood dyscrasias; G6PD deficiency; severe allergy or bronchial asthma; group A β-haemolysis streptococcal tonsillopharyngitis. Superinfection. Ensure adequate fluid intake. Monitor blood count regularly on long-term therapy. Renal & hepatic impairment. Not to be given during pregnancy. Lactation.