Class IA or III antiarrhythmics, multivalent cation-containing prep & mineral supplements, polymeric phosphate binders, sucralfate or antacids, highly buffered drugs containing Mg, Al, Ca, dairy products or mineral-fortified drinks. Increased serum conc w/ probenecid. Increased serum conc of tizanidine, theophylline, caffeine, pentoxifylline. Increased absorption w/ metoclopramide. Slight reduction of C
max & AUC w/ omeprazole. Inhibit renal tubular transport of MTX. Induced convulsions w/ NSAIDs. Increased serum creatinine conc w/ cyclosporin. Augmented anticoagulant effects of vit K antagonist. Intensified action of glibenclamide. Increased AUC & C
max of duloxetine, ropinirole & sildenafil. Reduced clearance of lidocaine IV.