Hypersensitivity: Cipquin should not be used where there is hypersensitivity to ciprofloxacin or to other chemotherapeutic agents of the quinolone group. In some instances, hypersensitivity and allergic reactions occurred after the first administration; the doctor should be informed immediately. Anaphylactic/anaphylactoid reactions in very rare instances and can progress to a life threatening shock. In these cases, Ciprofloxacin should be discontinued and medical treatment (e.g. treatment for shock) is required. Ciprofloxacin should be used with caution in the elderly, in patients with epilepsy or a history of CNS disorders, including cerebral arteriosclerosis (fluoroquinolones may cause CNS stimulation or toxicity).
Musculo-skeletal system: Achilles and other tendon ruptures that required surgical repair or resulted in prolonged disability have been reported predominantly in the elderly on prior treatment with glucocorticoids. Ciprofloxacin should be discontinued, physical exercises be avoided, and a physician be consulted, if the patient experiences pain, inflammation, or rupture of a tendon.
Care is necessary in patients with impaired hepatic or renal function (patients with both hepatic and renal function impairment may require a reduction in the dosage of ciprofloxacin), glucose-6-phosphate dehydrogenase deficiency, or myasthenia gravis. An adequate fluid intake should be maintained during treatment with ciprofloxacin and excessive alkalinity of the urine avoided because of the risk of crystalluria. Exposure to strong sunlight or sunlamps should also be avoided (discontinue if photosensitivity occurs).