Analgesics: Concurrent administration of fenbufen with quinolone antibiotics may increase the incidence of quinolone CNS adverse effects. Convulsions may occur due to an interaction between the quinolones and NSAIDs.
Iron, Sucralfate or Antacids and highly buffered drugs (e.g. anti-retrovirals) containing Magnesium, Aluminium or Calcium: The absorption of ciprofloxacin is reduced by antacids containing aluminium or magnesium and also by calcium, iron and zinc salts. Consequently, Cipquin should be taken either 1-2 hours before, or at least 4 hours after these preparations. This does not apply to antacids, which do not contain aluminium or magnesium hydroxide (e.g., H2-receptor blockers). Sucralfate releases aluminium ions in the stomach and thereby reduces the absorption of ciprofloxacin.
Antineoplastics and lmmunosuppressants: Absorption of oral ciprofloxacin appears to be reduced after cytotoxic chemotherapy.
Cyclosporin: A transient rise in the concentration of serum creatinine was observed when Cipquin and cyclosporin were administered simultaneously. Therefore, it is necessary to control the serum creatinine concentrations in these patients frequently (twice a week).
Xanthines: Concurrent administration of ciprofloxacin and theophylline can cause undesirable increase in the serum theophylline concentration. This can lead to theophylline-induced side effects; in very rare cases these side effects can be life threatening or fatal. If concurrent use of the two products is unavoidable, the serum theophylline concentration should be checked and the theophylline dose appropriately reduced.
Warfarin: Concurrent use of warfarin with ciprofloxacin has been reported to increase the anticoagulant effect of warfarin, increasing the chance of bleeding.
Glibenclamide: In particular cases, concurrent administration of ciprofloxacin and glibenclamide can intensify the action of glibenclamide (hypoglycaemia).
Probenecid: interferes with renal secretion of ciprofloxacin. Co-administration of probenecid and ciprofloxacin increases the ciprofloxacin serum concentrations.
Metoclopramide: accelerates the absorption of ciprofloxacin resulting in a shorter time to reach maximum plasma concentrations. No effect was seen on the bioavailability of ciprofloxacin.