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Administration: The tablets should be taken whole with a little fluid.
They do not need to be taken at mealtimes. Absorption of the drug is accelerated if taken on an empty stomach.
Elderly patients should receive as low a dose as possible, taking into account the severity of the illness and the creatinine clearance.
Renal and Hepatic Impairment: 1.0. Impaired Renal Function: 1.1. Where creatinine clearance is between 31 and 60 ml/min/1.73 m2 or where the serum creatinine concentration is between 1.4 and 1.9 mg/100 ml, the maximum daily dose should be 1000 mg/day for oral administration.
1.2. Where creatinine clearance is ≤ 30mL/min/1.73 m2 or where the serum creatinine concentration is ≥ 2 mg/100 ml, the maximum daily dose should be 500 mg/day for oral administration.
2.0. Impaired Renal Function + Haemodialysis: Dose as in 1.2; on dialysis days after dialysis.
3.0. Impaired Renal Function + CAPD: Administration of ciprofloxacin film coated tablets as 1 x 500 mg film coated tablet or 2 x 250 mg film coated tablets.
4.0 Impaired Liver Function: No dose adjustment is required.
5.0 Impaired Renal and Liver Function: Dose adjustment as in 1.1 and 1.2.