Chymotrypsin: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Malaysia prescribing information.

Generic Medicine Info

Indications and Dosage

Intraocular
Enzymatic zonulysis for intracapsular lens extraction

Adult: Irrigate the posterior chamber with 1-2 mL of a 1:5000 diluted soln (150 N.F.u/mL). Then irrigate with at least 2 mL of the unused portion of the diluent 2-4 min after procedure.

Contraindications

Hypersensitivity. High vitreous pressure & a gaping incisional wound, congenital cataracts, patients < 20 yr due to probable lens-vitreous adhesion not responsive to α-chymotrypsin lysis.

Adverse Reactions

IM: Occasionally, severe allergic reactions. Ophthalmological: Increased intraocular pressure, corneal oedema, striation & moderate uveitis.

Action

Description:
Mechanism of Action: Chymotrypsin is a proteolytic enzyme obtained by the activation of chymotrypsinogen extracted from the pancreas of beef that has been used in ophthalmology for the dissection of the zonule of the lens, thus facilitating intracapsular cataract extraction & reducing trauma to the eye. It has also been given for its anti-inflammatory actions eg, in soft-tissue inflammation & oedema.

MIMS Class

Anti-Inflammatory Enzymes

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