Chlorprothixene

Intramuscular
Psychoses

Oral
Psychoses

May be taken with or without food. Take w/ meals or milk if GI upset occurs.

Coma; CNS depression; pheochromocytoma.

Hepatic or renal impairment; history of jaundice; CV disease; angle-closure glaucoma; diabetes mellitus; hyperthyroidism; Parkinson's disease; epilepsy, depression, myasthenia gravis; prostatic hypertrophy; severe respiratory disease; blood dyscrasias. May precipitate coma, affect driving; elderly and children. Pregnancy and lactation

Dry mouth, constipation, urinary retention, mydriasis; agitation, insomnia, depression, convulsions, nasal congestion, tachycardia, postural hypotension, blurred vision, inhibition of ejaculation; urticaria, exfoliative dermatitis; agranulocytosis; extrapyramidal dysfunction; altered endocrine and metabolic functions.

ACE inhibitors, α-blockers, amantadine, general anaesthetics, angiotensin-II receptor antagonists, antiarrhythmics, tricyclic antidepressants, anxiolytics and hypnotics, apomorphine, artemether with lumefantrine, barbiturates, bromocriptine, cabergoline, calcium-channel blockers, carbamazepine, cimetidine, ethosuximide, levodopa, lisuride, memantine, methyldopa, metoclopramide, opioid analgesics, oxcarbazepine, pergolide, phenytoin, pramipexole, primidone, ritonavir, ropinirole, sibutramine, sympathomimetics, terfenadine, tetrabenazine, tramadol and valproate. Alcohol.

Immunologic urine pregnancy test; urine bilirubin test; serum uric acid concentrations.

Description:
Mechanism of Action: Chlorprothixene blocks postsynaptic dopamine receptors in the brain and also produces an α-adrenergic blocking effect thus depressing the release of hypothalamic and hypophyseal hormones. Prolactin levels are increased due to blockade of prolactin inhibitory factor. It also possesses antiemetic and sedative properties.

Antipsychotics