Gastrointestinal side effects (e.g. nausea, vomiting, diarrhea), may occur which, in individual cases, could necessitate discontinuation of treatment. Headache, dizziness, agitation and sleep disorders may occasionally occur as well as, in isolated cases intrahepatic cholestasis and transaminase elevation. There have been reports of flushing, occasionally tachycardia and rarely angina pectoris and hypotension, particularly if using high doses of Pentoxifylline. In such cases, discontinuation of the medication or a reduction of the daily dosage is required.
Hypersensitivity reactions such as pruritus, rash, urticaria, anaphylactic or anaphylactoid reactions with angioneurotic edema or bronchospasm may occur in isolated cases and usually disappear rapidly after discontinuation of the drug treatment.
A few very rare events of' bleeding (e.g. skin, mucosa) have been reported in patients treated with Pentoxifylline with and without anticoagulants or platelet aggregation inhibitors. The serious cases are predominantly concentrated in the gastrointestinal, genitourinary, multiple site and surgical wound areas and are associated with bleeding risk factors. A causal relationship between Pentoxifylline therapy and bleeding has not been established.
Thrombocytopenia has occurred in isolated cases.