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Indications and Dosage
Intramuscular
Pregnancy termination in the 2nd trimester Adult: Initially, 250 mcg. Alternatively, initiate w/ test dose of 100 mcg. May be repeated at 1.5- to 3.5-hr intervals depending on uterine response. May be increased to 500 mcg if uterine contractility is inadequate. Max: 12 mg. Max duration: 2 days. Intramuscular Postpartum haemorrhage Adult: Initially, 250 mcg by deep inj. May be repeated every 15-90-min. Max: 2 mg.
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Contraindications
Acute pelvic inflammatory disease; active cardiac, pulmonary, renal or hepatic disease.
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Special Precautions
Patient w/ compromised (scarred) uteri; history of asthma, seizure disorders, DM, anaemia, glaucoma or raised intra-ocular pressure, HTN, hypotension, CV disease, hepatic disease, including jaundice or renal disease. Pregnancy and lactation.
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Adverse Reactions
Vomiting, diarrhoea, nausea, transient fever, flushing, increased BP, bronchospasm, dyspnoea, pulmonary oedema.
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IM/Parenteral: C
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Patient Counseling Information
This drug may cause syncope, dizziness and somnolence, if affected, do not drive or use machines.
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Monitoring Parameters
Monitor for reductions in arterial-oxygen content in patients w/ cardiopulmonary disorders.
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Overdosage
Symptoms: HTN, increased body temp. Management: Symptomatic treatment.
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Drug Interactions
May potentiate effect of other oxytocics.
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Action
Description:
Mechanism of Action: Carboprost, a synthetic analogue of naturally occurring prostaglandin F2α, stimulates uterine contractility, resulting in expulsion of the products of conception. It is also used to induce abortion between 13-20 wk of pregnancy. It produces myometrial contractions responsible for placental haemostasis. Onset: Postpartum haemorrhage: Approx 45 min (increase in uterine tone and decreased bleeding). Pharmacokinetics: Absorption: Rapidly absorbed following IM admin. Time to peak plasma concentration: 20-30 min. Distribution: Crosses the placenta. Metabolism: Undergoes metabolism via omega-oxidation. Excretion: Via urine (83%) mainly as metabolites. |
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Chemical Structure
 Source: National Center for Biotechnology Information. PubChem Database. Carboprost tromethamine, CID=5281074, https://pubchem.ncbi.nlm.nih.gov/compound/Carboprost-tromethamine (accessed on Jan. 21, 2020) |
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Storage
Store between 2-8°C.
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MIMS Class
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ATC Classification
G02AD04 - carboprost ; Belongs to the class of prostaglandins. Used to induce abortion or augment labour and to minimize blood loss from the placental site.
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