Administer by slow IV infusion over approx 1 hr.
Adult Empirical therapy 70 mg single loading dose on Day 1, then 50 mg daily thereafter. Duration:
Fungal infection Min of 14 days; continue for at least 7 days after both neutropenia & clinical symptoms are resolved.
Invasive candidiasis 70 mg single loading dose on Day 1, then 50 mg daily thereafter. Continue for at least 14 days after last +ve culture.
Esophageal candidiasis 50 mg daily.
Invasive aspergillosis 70 mg single loading dose on Day 1, then 50 mg daily thereafter.
Co-administration w/ efavirenz, nevirapine, rifampicin, dexamethasone, phenytoin or carbamazepine 70 mg daily.
Moderate hepatic insufficiency (Child-Pugh score 7-9) 70 mg loading dose on Day 1, then 35 mg daily.
Childn 12 mth-17 yr 70 mg/m
2 single loading dose on Day 1, then 50 mg/m
2 daily thereafter.
Co-administration w/ drug inducers eg, rifampicin, efavirenz, nevirapine, phenytoin, dexamethasone or carbamazepine Not to exceed 70 mg/m
2 daily.