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Take special care with BREXIN and always tell the doctor before using BREXIN: Like all non-steroidal-anti-inflammatory drugs, BREXIN can cause serious reactions in the stomach and intestines, such as pain, bleeding and ulceration. The patient should immediately stop taking piroxicam and tell the doctor if the patient has stomach pain, or any sign of bleeding in the stomach or intestines, such as passing black or bloodstained bowel movements, or vomiting blood.
The patient should immediately stop taking BREXIN and tell the doctor if the patient has any allergic reaction such as skin rash, swelling of the face, wheezing or difficulty in breathing.
If patient is over 70 years old, the doctor may wish to minimise treatment duration, and to see the patient more often while they are taking BREXIN.
If the patient is over 70 years old, or the patient is taking other medicines like corticosteroids or certain drugs for depression called selective serotonin reuptake inhibitors (SSRIs), or acetyl-salicylic acid to prevent blood clotting, the doctor may like to prescribe medicine for protecting their stomach and intestines.
Patient should not be use this medicine if the patient is older than 80 years.
If the patient has or had any medical problems or any allergies or if the patient is not sure as to whether the patient can use BREXIN, they should tell the doctor before using this medicine.
The patient must make sure that the patient have told the doctor about any other medicines that the patient is taking, including those that the patient has brought without a prescription.
Medicines like BREXIN may be associated to an increased risk of heart attack (myocardial infarction) or stroke. Any risk is more likely to occur with high doses and prolonged treatments. Do not exceed the recommended dose or duration of treatment. If the patient has heart problems, or had stroke or think to be at risk for these conditions (for example, if the patient has high blood pressure, diabetes or high cholesterol levels or smoke addiction) the patient should discuss the therapy with the doctor or pharmacist. BREXIN, like other non-steroidal anti-inflammatory drugs, decreases platelet aggregation and prolongs coagulation time; this should be taken into account when the patient undergoes blood testing and requires vigilance when the patient is concomitantly taking drugs inhibiting platelet aggregation.
Caution is required if the patient has a history of hypertension and/or heart failure, as water retention and oedema have been reported with NSAIDs therapy. Particular caution is required in patients with cardio-circular failure, hypertension, reduced hepatic or renal function, poor renal perfusion, active or previous blood alterations and if the patient is taking diuretics.
If the patient is asthmatic, due to the drug interaction with arachidonic acid metabolism, broncho-spastic attacks and eventually shocks, and other allergic reactions may occur.
As some ocular changes were observed during therapy with NSAIDs, periodic ophthalmologic checks are advised during prolonged treatment.
As for other drugs with similar action, some patients showed increase of blood urea nitrogen not exceeding certain levels, in case of prolonged treatment; once therapy is discontinued, values return to baseline.
If the patient is diabetic, it is advisable to perform frequent blood testing.
Severe allergic reactions (especially severe skin reactions) were very rarely reported with the use of NSAIDs. (See Adverse Reactions.)
In case the patient is programming a pregnancy, if the patient has fertility problems or in case the patient is undergoing fertility tests, the patient must discuss therapy with the doctor.
Important information on some excipients of BREXIN: The dosage forms tablets contain lactose: if the patient have a diagnosed intolerance to some sugars, the patient must contact the doctor before taking this medicine.
Ability to Drive or Use Machines: In case of dizziness or unusual tiredness, patient must pay particular attention while driving or operating machines.
