Side effects are uncommon while using glucosamine sulfate.
Cardiovascular: Peripheral oedema and tachycardia were reported in a few patients following larger clinical trials investigating oral administration in osteoarthritis. A causal relationship has not been established.
Central nervous system: Drowsiness, headache and insomnia have been observed rarely during therapy (less than 1%).
Gastrointestinal: Nausea, vomiting, diarrhoea, dyspepsia or epigastric pain, constipation, heartburn and anorexia have been described rarely during oral therapy with glucosamine.
Skin: Skin reactions such as erythema and pruritus have been reported with therapeutic administration of glucosamine.