Discontinue use at 1st appearance of skin rash, mucosal lesions or any other sign of hypersensitivity; persistent abnormal LFTs are detected. Not a substitute for aspirin in CV prophylaxis. Increased risk of GI ulceration, bleeding & perforation. History of serious GI events & other risk factors associated w/ PUD eg, alcoholism, smoking, corticosteroid therapy; cardiac failure, left ventricular dysfunction. Significant risk factors for CV events eg, HTN, hyperlipidaemia, DM; preexisting oedema; peripheral arterial disease. May mask fever. Ensure adequate hydration prior to therapy. Monitor BP 2 wk after initiation & periodically thereafter. Monitor renal function in patients w/ preexisting significant renal impairment, uncompensated heart failure or cirrhosis. Concomitant use w/ NSAIDs, other NSAIDs or ASA even at low doses; warfarin or other oral anticoagulants. Not recommended in advanced renal disease (CrCl <30 mL/min). Not recommended in women of childbearing potential. Not to be used during pregnancy & lactation. Elderly ≥65 yr, debilitated patients.