Adult: As soln (containing betamethasone dipropionate 0.05% w/w and salicylic acid 2% w/w) or oint (containing betamethasone dipropionate 0.05% w/w and salicylic acid 3% w/w or betamethasone valerate 0.1% w/w and salicylic acid 3% w/w): Apply to the affected area 1-2 times daily for 2 wk. Max: 60 g wkly. Child: Max duration: 5 days.
Symptoms: Pituitary-adrenal suppression resulting in secondary adrenal insufficiency and produce manifestations of hypercorticism, including Cushing's disease. Salicyclism symptoms. Management: Symptomatic and supportive treatment. Treat electrolyte imbalance. Slow withdrawal in case of chronic toxicity. Admin oral Na bicarbonate to alkalinise the urine and force diuresis.
Description: Mechanism of Action: Betamethasone is a synthetic fluorinated corticosteroid. It is active topically and produces a rapid and sustained response in inflammatory dermatoses. Salicylic acid has keratolytic action. It softens keratin, loosens cornified epithelium and desquamates the epidermis. It aids in the penetration of betamethasone. Pharmacokinetics: Absorption: Betamethasone: Percutaneous absorption depends on several factors e.g. use of occlusive dressings and integrity of the epidermal barrier. Salicylic acid: Exerts only local action after topical application. Distribution: Betamethasone: Rapidly distributed to all body tissues. Crosses the placenta; enters breast milk (small amounts). Plasma protein binding: Extensive (mainly to globulin). Metabolism: Betamethasone: Metabolised mainly in the liver. Excretion: Betamethasone: Via urine; may also be excreted via the bile.
Betosalic Ointment (T.O. Chemicals). MIMS Thailand. http://www.mims.com/thailand. Accessed 07/08/2015.Buckingham R (ed). Pharmacokinetics of Corticosteroids. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 07/08/2015.McEvoy GK, Snow EK, Miller J et al (eds). Betamethasone, Betamethasone Benzoate, Betamethasone Dipropionate, Betamethasone Valerate (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 07/08/2015.