Adult: As gel, oint, foam or susp containing betamethasone dipropionate 0.05% and calcipotriol 0.005%: Apply to affected area once daily. Duration of therapy: Up to 4 wk (scalp area) or 8 wk (non-scalp area). Treatment may be continued or repeated if necessary, after medical review and under regular medical supervision. Max: 15 g daily. Apply to max 30% of body surface.
Known or suspected disorder of Ca metabolism. Erythrodermic, exfoliative and pustular psoriasis; viral lesions of the skin, fungal or bacterial skin infections, parasitic infections, skin manifestations in relation to TB, perioral dermatitis, atrophic skin, striae atrophicae, fragility of skin veins, ichthyosis, acne vulgaris, rosacea, ulcers and wounds.
Additive adverse effects when used w/ other steroids.
Description: Mechanism of Action: Betamethasone is a synthetic corticosteroid that has anti-inflammatory, antipruritic and vasoconstrictive properties. Calcipotriol is a vit D analogue. It induces differentiation and suppresses proliferation of keratinocytes. However, the exact mechanism of their actions in psoriasis vulgaris are uncertain. Pharmacokinetics: Absorption: <1% is systemically absorbed through normal skin. Distribution: Enters breast milk (betamethasone). Plasma protein binding: Approx 64%. Metabolism: Rapidly and extensively metabolised in the liver. Excretion: Betamethasone: Via urine. Calcipotriol: Via faeces.
D07XC01 - betamethasone ; Belongs to the class of potent (group III) corticosteroids in other combinations. Used in the treatment of dermatological diseases. D05AX02 - calcipotriol ; Belongs to the class of other antipsoriatics for topical use. D07AC01 - betamethasone ; Belongs to the class of potent (group III) corticosteroids. Used in the treatment of dermatological diseases. D05AX52 - calcipotriol, combinations ; Belongs to the class of other antipsoriatics for topical use.
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