Adverse reactions occur in approximately 10% of the patients and they are usually dose-related.
Heart: Common: Bradycardia, palpitations. Less common: Chest pain, transient aggravation of heart failure, cardiogenic shock in patients with acute myocardial infarction. Rare: Prolonged AV-conduction time, cardiac arrhythmias.
Blood and lymphatic system: Rare: Thrombocytopenia.
Central and peripheral nervous system: Common: Dizziness, headache. Less common: Paraesthesia.
Eyes: Rare: Visual disturbances, dry and/or irritated eyes. Frequency unknown: Conjunctivitis.
Ear and balance organ: Rare: Tinnitus.
Respiratory: Common: Shortness of breath when physically active. Less common: Bronchospasm in patients with bronchial asthma or asthmatic problems. Frequency unknown: Rhinitis.
Gastrointestinal: Common: Abdominal pain, nausea, vomiting, diarrhea, constipation. Rare: Taste changes. Frequency unknown: Dry mouth.
Skin and subcutaneous tissue: Less common: Hypersensitivity reactions in the skin. Rare: Aggravated psoriasis, photosensitivity reactions, hyperhidrosis, hair loss.
Musculoskeletal system and connective tissue: Frequency unknown: Muscle cramps, arthralgia.
Vascular: Common: Peripheral coldness in extremities. Rare: Syncope. Frequency unknown: Gangrene in patients with severe peripheral vascular disorders.
General symptoms and/or symptoms at administration site: Very common: Fatigue. Less common: Oedema, weight gain.
Liver and biliary tracts: Rare: Elevated transaminases. Frequency unknown: Hepatitis.
Reproductive organs and mammary glands: Rare: Reversible libido dysfunction.
Psychiatric disorders: Less common: Depression, nightmares, sleeping disturbance. Rare: Memory impairment, confusion, hallucinations, nervousness, anxiety. Frequency unknown: Impaired concentration ability.