Not to be inj as IV push or bolus. Discontinue use if progressive multifocal leukoencephalopathy is confirmed. Not recommended in severe active CNS lupus. History of multiple drug allergies or significant hypersensitivity. Increased risk of infections & malignancies. Psychiatric disorders eg, depression, suicidal ideation & behaviour. Avoid immunisation 30 days before & during therapy. Concomitant use w/ other B-cell targeted therapy. Renal & hepatic impairment. Women of childbearing potential should use adequate contraception during & at least 4 mth after treatment. Pregnancy & lactation. Not recommended to be used in childn & adolescents w/ active lupus nephritis. Childn <18 yr. Not recommended in elderly.
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 120 mg73dcb5e8-4aa0-4d68-966c-a427010f36d0.GIF)
