Methyl salicylate, menthol, camphor.
Methyl salicylate 30 g, menthol 10 g, camphor 4 g.
Pharmacotherapeutic group: Analgesic (Topical).
Pharmacology: METHYL SALICYLATE: Methyl salicylate is extensively metabolized to salicylic acid in the dermal and subcutaneous tissues following topical administration.
Results from another study demonstrating high tissue to plasma ratios following topical application of Methyl salicylate formulation suggest that direct penetration and not recirculation in the blood is responsible for the salicylate concentrations found.
Methyl salicylate may be absorbed through intact skin. Percutaneous absorption is enhanced by exercise, heat, occlusion, or disruption of the integrity of the skin. The amount absorbed will also be increased by application to large areas of skin. Results from a study in healthy subjects demonstrated that a considerable amount of salicylic acid may be absorbed through the skin after topical application of products containing Methyl salicylate.
MENTHOL: When applied to the skin it dilates the blood vessels, causing a sensation of coldness followed by an analgesic effect.
After absorption, Menthol is excreted in the urine and bile as a glucuronide.
CAMPHOR: Camphor is readily absorbed from all administration sites. It is hydroxylated in the liver to yield hydroxycamphor metabolites which are then conjugated with glucuronic acid and excreted in the urine.
Camphor crosses the placenta.
Indicated for temporary relief of minor aches and pains of muscle and joints associated with simple backache, arthritis, strains, etc.
Topical.
Apply to the affected areas, 2-3 times daily.
Mild chronic salicylate intoxication, or salicylism, usually occurs only after repeated use of large doses.
Salicylism can also occur following excessive topical application of salicylates. Symptoms include dizziness, tinnitus, deafness, sweating, nausea and vomiting, headache, and confusion, and may be controlled by reducing the dosage.
It is contraindicated in patients hypersensitive to any of the active ingredients. Can cause convulsion, contraindicated in infants below 2 years of age.
This product is for external use only.
If condition worsens, or if symptoms persist for more than 7 days or clear up and occur again within a few days, discontinue use of this product and consult a doctor.
Do not apply to wounds or damaged skin.
Do not apply over large areas of the body or bandage.
It is dangerous to place any camphor containing product into the nostril of children. A small amount applied this way may cause immediate collapse.
Use in children: This product is contraindicated in children below 2 years of age.
Caution should be exercised when older children are treated.
Skin irritation, redness or swelling, burning or stinging sensation. Adverse reaction is rare symptom of dizziness, nausea may occur.
For EXTERNAL USE ONLY. Use only as directed.
Store at temperature of not more than 30ºC.
M02AC - Preparations with salicylic acid derivatives ; Used in the topical treatment of joint and muscular pains.
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