Azithro Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Warnings Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Azithromycin

Indications/Uses

Lower resp tract infections eg, bronchitis & pneumonia, odontostomatological, skin & soft tissue infections, acute otitis media; URTI eg, sinusitis, pharyngitis/tonsillitis. Uncomplicated genital infection due to Chlamydia trachomatis & non-multiresistant Neisseria gonorrhoea & chancroid due to Haemophilus ducreyi. Prophylaxis against Mycobacterium avium-intracellulare complex (MAC) alone or in combination w/ rifabutin. In combination w/ ethambutol for disseminated MAC (DMAC).

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Dosage/Direction for Use

Adult including elderly STD caused by Chlamydia trachomatis, Haemophilus ducreyi or susceptible Neisseria gonorrhoea 1,000 mg as single oral dose. Prophylaxis against MAC infections HIV 1,200 mg once/wk. DMAC infections Advanced HIV 600 mg once daily in combination w/ antimycobacterial agents eg, ethambutol at approved dose. Other indications Total dose: 1,500 mg given as 500 mg daily for 3 days. Childn >45 kg & elderly Same as adult dose.

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Overdosage

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Administration

Should be taken on an empty stomach: Take at least 1 hr before or 2 hr after food.

Contraindications

Hypersensitivity to azithromycin or any macrolide antibiotics.

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Warnings

For additional cautionary notes to warn of the potential risk of using the medicine... Click to view Azithro detailed prescribing information

Special Precautions

Hypersensitivity; anaphylaxis, severe cutaneous ARs (SCARs) including SJS, TEN, DRESS & acute generalized exanthematous pustulosis. Congenital or documented QT interval prolongation, electrolyte disturbances, clinically relevant bradycardia, cardiac arrhythmia or insufficiency. Observe for signs of superinfection w/ non-susceptible organisms eg, fungi. Not to be co-administered w/ ergot derivatives. Concurrent use w/ QT interval prolonging substances eg, class IA & III antiarrhythmics, antipsychotics, antidepressants, fluoroquinolones. Significant hepatic disease. Severe renal impairment. Pregnancy & lactation. Infantile hypertrophic pyloric stenosis. Elderly.

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Use In Pregnancy & Lactation

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Adverse Reactions

GI disturbances, mild neutropenia, abnormal liver function, hearing impairment. HIV patients: Diarrhea, abdominal pain, nausea, loose stools, flatulence, vomiting, dyspepsia, rash, pruritus, arthralgia. Asthenia; SCARs including SJS, TEN, DRESS & acute generalized exanthematous pustulosis.

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Drug Interactions

Impaired metabolism of digoxin. Little effect on plasma pharmacokinetics or urinary excretion of zidovudine. Possibility of ergotism w/ ergot derivatives. Monitor prothrombin time w/ coumarin-type oral anticoagulants; cyclosporin levels. Neutropenia was observed w/ rifabutin. Possible interaction w/ terfenadine.

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Storage

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Description

View Azithro description for details of the chemical structure and excipients (inactive components).

Action

View Azithro mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Macrolides

ATC Classification

J01FA10 - azithromycin ; Belongs to the class of macrolides. Used in the systemic treatment of infections.

Regulatory Classification

Presentation/Packing

Form

Azithro cap 250 mg

Packing/Price

6's

Azithro

azithromycin

Manufacturer:

M & H

Distributor:

Germax