Concise Prescribing Info
Azithromycin dihydrate
Lower & upper rest tract, skin & soft tissue infections, acute otitis media. STD, uncomplicated genital infections due to Chlamydia trachomatis & non-multiresistant Neisseria gonorrhoea, chancroid due to Haemophilus ducreyi; concurrent infection w/ Treponema pallidum should be excluded. Alone or in combination w/ rifabutin for prophylaxis against Mycobacterium avium-intracellulare complex (MAC) infection & in combination w/ ethambutol for disseminated MAC (DMAC) infection in patients w/ advanced HIV infection.
Dosage/Direction for Use
Adult & elderly STD caused by Chlamydia trachomatis, Haemophilus ducreyi or susceptible Neisseria gonorrhoea 1,000 mg as single dose. Other indications Total dosage: 1,500 mg, may be given as 500 mg daily for 3 days or 500 mg on day 1, then 250 mg on days 2-5. Prophlaxis against MAC infections in patient w/ HIV infection 1,200 mg once wkly. DMAC infections in patient w/ advanced HIV infection 600 mg once daily.
Should be taken on an empty stomach: Take at least 1 hr before or 2 hr after meals.
Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic.
Special Precautions
Discontinue use if severe acute hypersensitivity reactions occur. Superinfection; known QT interval prolongation, history of Torsade de pointes, congenital long QT syndrome, bradyarrhythmias or uncompensated heart failure, ongoing proarrhythmic conditions eg, uncorrected hypokalemia or hypomagnesemia, clinically significant bradycardia. Infantile hypertrophic pyloric stenosis. Not to be co-administered w/ ergot derivatives. Concomitant use w/ QT interval-prolonging drugs & class IA or III antiarrhythmic agents. Severe renal impairment. Significant hepatic disease. Pregnancy. Not to be used during lactation. Not suitable for childn <45 kg. Elderly.
Adverse Reactions
Diarrhea. Headache; vomiting, abdominal pain, nausea; decreased lymphocyte count & blood bicarbonate, increased eosinophil count, basophils, monocytes & neutrophils.
Drug Interactions
Reduced peak serum conc w/ antacids. Raised digoxin levels. Increased conc of phosphorylated zidovudine. Ergotism w/ ergot derivatives. Monitor cyclosporin levels.
MIMS Class
ATC Classification
J01FA10 - azithromycin ; Belongs to the class of macrolides. Used in the systemic treatment of infections.
Azicine hard cap 250 mg
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