Discontinue use if severe cutaneous ARs occur. Not as 1st choice for pharyngitis & tonsillitis caused by
Streptococcus pyogenes; sinusitis; acute otitis media. Not indicated for infected burn wounds. Superinfection;
Clostridium difficile-associated diarrhoea; congenital or documented QT prolongation; electrolyte disturbance; clinically relevant bradycardia, cardiac arrhythmia or insufficiency; myasthenia gravis; infantile hypertrophic pyloric stenosis; neurological or psychiatric disorders. Ensure susceptibility testing prior to treatment of skin & soft tissue infection. Not to be co-administered w/ ergot derivatives. Concomitant use w/ drugs prolonging QT interval eg, class IA & III antiarrhythmics; cisapride, terfenadine; antipsychotics; antidepressants; fluoroquinolones; hepatotoxic drugs. May affect ability to drive & use machines. Significant hepatic disease; fulminant hepatitis, preexisting hepatic disease; severe renal impairment (GFR <10 mL/min). Pregnancy & lactation. Childn. Elderly.