Discontinue use if necrotising fasciitis develops. History of CV or pulmonary disease; tumour lysis syndrome. Perform CBC & determine LFTs, serum creatinine & bicarbonate prior to initiation & each treatment cycle. Assess cardiopulmonary prior to & during treatment. May affect ability to drive & use machines. Hepatic & renal impairment. Women of childbearing potential & men should use effective contraception during & up to 3 mth after treatment. Not to be used during 1st trimester of pregnancy.
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