Adult & elderlyMild to moderate Alzheimer's disease 5 mg once daily at bedtime, may be increased to max: 10 mg once daily following 1 mth of clinical assessment. Severe Alzheimer's disease 10 mg once daily.
NMS. Sick sinus syndrome or other supraventricular cardiac conduction conditions eg, SA or AV block; syncope or seizures; bladder outflow obstruction. Preexisting or history of QTc prolongation; Torsade de pointes; preexisting cardiac disease eg, uncompensated heart failure, recent MI, bradyarrhythmias; electrolyte disturbances eg, hypokalaemia, hypomagnesaemia. History of ulcer disease, asthma or obstructive pulmonary disease. May exacerbate/induce extrapyramidal symptoms. Concomitant use w/ succinylcholine-type anaesth; drugs affecting QTc interval. Concurrent use w/ NSAIDs. Avoid use w/ inhibitors of acetylcholinesterase agonists or cholinergic system antagonists. May affect ability to drive & use machines. Severe hepatic impairment. Not to be used during pregnancy & lactation. Not recommended in childn.
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