Allergic reaction to protamine, fish. Not suitable for reversing effects of oral anticoagulants. Patients previously undergone coronary angioplasty or cardiopulmonary bypass, diabetics treated w/ protamine insulin, men who have had vasectomy or are infertile; Ab to protamine. Avoid too rapid administration. Carefully monitor clotting parameters during prolonged procedures using repeated protamine doses. Pregnancy & lactation. Not recommended in childn.