Counteract anticoagulant effects of heparin pre-op; after renal dialysis & open heart surgery; if excessive bleeding occurs; when overdose has inadvertently been given.
Individualized dosage. Adult No >50 mg slow IV inj over 10 min. Unfractioned heparin neutralisation 1 mg for at least 100 IU mucous heparin or 80 u lung heparin, may be reduced if >15 min elapsed since IV inj. LMWH neutralisation 1 mg/100 u.
Allergic reaction to protamine, fish. Not suitable for reversing effects of oral anticoagulants. Patients previously undergone coronary angioplasty or cardiopulmonary bypass, diabetics treated w/ protamine insulin, men who have had vasectomy or are infertile; Ab to protamine. Avoid too rapid administration. Carefully monitor clotting parameters during prolonged procedures using repeated protamine doses. Pregnancy & lactation. Not recommended in childn.
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