Tab Multiple myeloma 0.15 mg/kg daily in divided doses for 4 days repeated at 6-wk intervals.
Advanced ovarian adenocarcinoma 0.2 mg/kg daily for 5 days every 4-8 wk.
Breast carcinoma 0.15 mg/kg or 6 mg/m
2 daily for 5 days & repeated every 6 wk.
Polycythaemia rubra vera Remission induction: 6-10 mg daily for 5-7 days, then 2-4 mg daily until satisfactory disease control is achieved. Maintenance: 2-6 mg once wkly.
Inj Multiple myeloma Intermittent basis alone or in combination w/ other cytotoxic drugs: 8-30 mg/m
2 given at 2-6 wk intervals. Monotherapy: 0.4 mg/kg IV repeated at appropriate intervals.
Advanced ovarian adenocarcinoma Monotherapy: 1 mg/kg given at 4-wk intervals. Combination therapy: 0.3-0.4 mg/kg given at 4-6 wk intervals.
Advanced neuroblastoma in childhood 100-240 mg/m
2 together w/ hematopoietic stem cell rescue, alone or in combination w/ RT &/or other cytotoxic drugs.
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