Early hemarthrosis, mild muscle or oral bleeding 20-40 IU/dL or 10-20 IU/kg every 12-24 hr until bleeding is resolved.
Muscle bleeding, moderate oral cavity bleeding, definite hemarthroses, known trauma 30-60 IU/dL or 15-30 IU/kg every 12-24 hr until bleeding is resolved.
Significant GI, CNS, intracranial, intra-abdominal & intrathoracic bleeding, retropharyngeal or retroperitoneal spaces or iliopsoas sheath bleeding, fractures, head trauma 60-100 IU/dL or 30-50 IU/kg every 8-24 hr until bleeding is resolved.
Minor surgery including tooth extraction 30-60 IU/dL or 30-50 IU/kg 1 hr before surgery, repeat after 24 hr if necessary until bleeding is resolved.
Major pre- & post-op surgery eg, intracranial, intra-abdominal or intrathoracic surgery, joint replacement surgery 80-100 IU/dL or 40-60 IU/kg 1 hr before surgery, repeat every 8-24 hr (6-24 hr for childn <12 yr) until adequate wound healing.
Routine prophylaxis Adult & adolescent ≥12 yr 40-50 IU/kg twice wkly,
childn <12 yr 55 IU/kg twice wkly. Max: 70 IU/kg. Adjust dose & dosing intervals based on patient's clinical response.
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