Advate

Advate

octocog alfa

Manufacturer:

Takeda

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Octocog alfa (recombinant human coagulation factor VIII)
Indications/Uses
Treatment & prophylaxis of bleeding in patients w/ haemophilia A (congenital factor VIII deficiency). Not indicated in von Willebrand's disease.
Dosage/Direction for Use
Early haemarthrosis, muscle or oral bleeding 20-40 IU/dL every 12-24 hr (8-24 hr for patient <6 yr) for at least 1 day or until resolved. More extensive haemarthrosis, muscle bleeding or haematoma 30-60 IU/dL every 12-24 hr (8-24 hr for patient <6 yr) for 3-4 days or until resolved. Life-threatening haemorrhage 60-100 IU/dL every 8-24 hr (6-12 hr for patient <6 yr) until resolved. Minor surgery eg, tooth extraction 30-60 IU/dL every 24 hr (12-24 hr for patient <6 yr) for at least 1 day or until healing. Major pre- & post-op surgery 80-100 IU/dL every 8-24 hr (6-24 hr for patient <6 yr) until adequate wound healing, then continue for at least another 7 days. Long-term prophylaxis against bleeding in patient w/ severe haemophilia A 20-40 IU/kg at 2-3 days interval. Paed patient <6 yr 20-50 IU/kg 3-4 times wkly.
Contraindications
Hypersensitivity to octocog alfa, mouse or hamster proteins.
Special Precautions
Discontinue use if hypersensitivity reactions occurs. Central venous access device-related complications eg, local infections, bacteremia & catheter site thrombosis. Monitor for development of factor VIII inhibitors. Controlled Na diet. Pregnancy & lactation.
Adverse Reactions
Factor VIII inhibition (previously-untreated patients). Headache; pyrexia.
MIMS Class
Haemostatics
ATC Classification
B02BD02 - coagulation factor VIII ; Belongs to the class of blood coagulation factors. Used in the treatment of hemorrhage.
Presentation/Packing
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Advate powd for inj 1,000 IU
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Advate powd for inj 1,500 IU
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Advate powd for inj 250 IU
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Advate powd for inj 500 IU
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