Instructions to Be Given to Patients: Patients should inform their physicians immediately if pain develops at the injection site.
Nausea and vomiting may be expected 3-6 hours after drug treatment, and may last for several hours.
Patients should be advised to expect a red colouration to the urine (not indicative of haematuria) for 1 to 2 days after each administration of ADRIAMYCIN.
Alopecia (hair loss) should be expected 1 to 2 weeks after the initiation of ADRIAMYCIN treatment. Hair loss may be complete but hair always returns after termination of treatment.
NB. Scalp tourniquets inflated to above systolic blood pressure and left in situ for 30 minutes over the time of ADRIAMYCIN treatment reduces the probability of alopecia.
Anorexia may be expected for 24 hours following each treatment and occasionally may persist for several days.
Hyperpigmentation, usually in the hands, nails and buccal mucosa may develop in patients receiving ADRIAMYCIN. Patients should be advised that this condition does not usually improve after termination of treatment.
Infertility in both sexes is usual in patients receiving ADRIAMYCIN. Amenorrhoea is frequent and in pre-menopausal women, regular menstruation usually returns a few months after termination of ADRIAMYCIN therapy. This is often accompanied by normal fertility.
Male patients should be advised that oligospermia or azoospermia may be permanent. There is a possibility that fertility may return several years after ceasing therapy. Men undergoing ADRIAMYCIN therapy should be advised to use effective contraceptive measures.
Patients should be instructed to inform their physicians of any prior abnormal heart or liver conditions, as this information is vital to the formulation of appropriate dosage regimes.