Aclarubicin


Generic Medicine Info
Indications and Dosage
Intravenous
Malignant blood disorders
Adult: Initially: 175-300 mg/m2 given in divided doses over 3-7 consecutive days via IV infusion over 30-60 minutes. Maintenance: 25-100 mg/m2 in a single infusion every 3-4 wk.
Contraindications
Pregnancy, lactation; CV disease.
Special Precautions
Myocardial irradiation and use of radiotherapy. Hepatic or renal impairment. Elderly.
Adverse Reactions
Nausea, vomiting, mucositis, irritant to tissue, sore mouth, bone-marrow suppression, hyperuricaemia. Alopoecia (rare).
Potentially Fatal: Cardiotoxicity (rare), myelosuppression in patients who received mitomycin or a nitrosourea, leucopenia.
Drug Interactions
Other cardiotoxic drugs e.g. daunorubicin or cyclophosphamide, live vaccines; decreases effects of digoxin, oral anticoagulants, phenytoin and suxamethonium.
Lab Interference
Elevated bilirubin level.
Action
Description:
Mechanism of Action: Aclarubicin is an anthracycline, a cytotoxic antibiotic, and inhibits RNA synthesis through intercalation.
Pharmacokinetics:
Distribution: Rapidly distributed into tissues after IV admin.
Metabolism: Extensively metabolised.
Excretion: Triphasic clearance. Terminal elimination half-life: About 3 hr. Excreted in urine mainly as metabolites.
MIMS Class
Cytotoxic Chemotherapy
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